Which genes are involved in
Associate Professor Justin Rubio and his Co-investigators Associate Professor Stephen Leslie and Associate Professor Michael Barnett have been awarded a MS Research Australia Project Grant for two years investigating the DNA from single cells in the brain to better understand progressive MS.
MS is a very varied diseased. Currently, we cannot predict the course an individual person’s disease with take. The majority of people are originally diagnosed with relapsing-remitting MS, of those close to 60% will eventually go on to develop secondary progressive MS, whereas others don’t. However, it is unclear what factors are responsible for the transition to progressive disease. While large genetic studies have identified over 100 genes involved in the risk of developing relapsing-remitting MS, similar studies in progressive MS have not found risk genes that leads to the transition to progressive forms of MS.
Associate Professor Rubio is examining the DNA and genes of individual brain cells of people with MS. This is because not all cells in our bodies are the same, even though they start off containing the same DNA, individual cells can develop genetic mutations as we age. These mutations in individual cells may influence the way those cells act and function. Associate Professor Rubio hypotheses that mutations in individual brain cells in people with MS might be responsible for the development of progressive MS.
In this project, Associate Professor Rubio and his team will isolate single cells from the brains of people who had MS. Using a process called Next Generation Sequencing, his team will then study the DNA of these cells, he is hoping to determine which genes are involved in progressive MS. This could pave the way for the development of new therapies for progressive MS.