Dr Linda Ly puts brains to
in new research
Linda Ly has made great progress in the first year of her three year fellowship
funded by the Trish Foundation.
at the University of Sydney and working with A/Prof Michael Barnett, Dr Ly is
focusing on research that will benefit those with progressive MS by
investigating repair processes in MS.
myelin can be repaired in the early relapsing stages of MS, however, in
progressive MS this remyelination process fails. This is also the stage where
people begin accumulating disability and new therapeutic strategies are
Dr Ly’s research focuses
on proteins and their relationship to lesions in the brain and spinal cord of
people with MS. She is using post-mortem tissue donated through the MSRA Brain
Bank. By comparing different stages of lesions, for example lesions which have
undergone repair vs. those where repair processes have failed, she hopes to identify a
molecular ‘signature’ for remyelination in MS.
Work is now well underway, using methods Dr Ly previously developed to
work with archived post-mortem MS brain and spinal cord tissue. She has
characterised 53 separate regions of tissue and identified 199 proteins which
were found in different amounts across the lesion stages. 25 of these proteins
are likely to have functions within the remyelination process and these
proteins are now the subject of a range of follow-up analyses to further detail
their role in MS tissue.
‘With further analysis, it is
hoped the identification of these proteins may lead to more effective
treatments to promote the regenerative processes in MS’ said Dr Ly. This will
hopefully lead to new treatment options for those with the progressive form of