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Feb 2017
Trish Foundation contributes to first-ever discovery
Jun 2017
Researchers funded by the Trish Foundation making great progress
Dec 2017
Announcement by NHMRC
Jan 2018
2018 Round of Funding Four new Projects announced
Jun 2018
Exciting regrowth of nerve fibres
Jun 2018
Dr Merson secures $1 million from NHMRC
Jun 2018
Findings submitted for publication
Jan 2019
New Research Projects commencing 2019 announced

Edwin Lim on target for

progressive MS


Dr Edwin Lim is a talented young researcher who completed his PhD in MS in 2010. In 2011, Dr Lim was awarded a three year grant partly funded by the Trish MS Research Foundation to support his innovative project searching for new diagnostic and therapeutic targets in MS. Dr Lim is investigating the role of tryptophan metabolism in MS. Originally based at the University of NSW, Dr Lim is now working alongside Dr Gilles Guillemin at Macquarie University.

Tryptophan is a naturally occurring amino acid that is used by the body as one of the building blocks of protein and is involved in many aspects of repair in the body. Dr Lim has discovered that the pathway that breaks down tryptophan does not function as it should in the MS brain and that this leads to the production of active toxins. Tracking the amount of this toxin may be useful as a way of determining the amount of damage in the brain and represents a potential biomarker for identifying disease activity in MS.

When Dr Lim blocked the tryptophan pathway using inhibitory molecules in laboratory models of MS, he found that he could limit the production of toxins and reverse the progression of disease. This raises the exciting possibility that blocking this pathway, and in particular the use of these molecules, may be an important therapeutic approach for MS.

In his continuing work, Dr Lim will examine the specific effect of these molecules on brain support cells, both on cells grown in the laboratory and in laboratory models of MS. This work should determine the exact mechanism underpinning the promising effects Dr Lim has seen so far, with these further results expected by the end of 2013.  

Trish Foundation & MS Research Australia Working together to find a cure for MS
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