Natalie Payne –
of Stem Cells to Treat MS
Trish Foundation Postgraduate Research Scholar
Natalie Payne has completed her Research Project at the Monash Immunology and Stem Cell Laboratories, Monash
has been working diligently investigating the therapeutic potential of
different types of neural stem cells to treat MS. Natalie has performed
extensive characterisation studies using a number of different stem cell lines,
an important prerequisite for therapeutic application of stem cell-based
therapies in humans.
of these stem cells to mice with a chronic progressive or a relapsing remitting
MS-like disease resulted in suppression of both the clinical and pathological
signs of disease. Through these studies Natalie has shown that tissue-specific
stem cells can differ considerably in terms of their stem cell-like properties
and therapeutic effect in vivo.
exploiting tissue-specific stem cells as vehicles for delivery of the
anti-inflammatory molecule Natalie was able to prevent development of chronic
progressive EAE. Natalie’s research in
2010 focused on the biological processes behind this effect as well as
examining the fate of transplanted stem cells using live animal imaging
recognition of her growing expertise and contribution to the field, Natalie has
authored two review articles that describe the application of stem cells for
the treatment of MS.
Breaking news October 2012:
Trish Foundation’s PhD Scholar makes a significant contribution
researchers have discovered that stem cells derived from fat tissue are more
effective in reaching the brain and spinal cord in a mouse model of MS than
stem cells from bone marrow.