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Feb 2017
Trish Foundation contributes to first-ever discovery
Jun 2017
Researchers funded by the Trish Foundation making great progress
Dec 2017
Announcement by NHMRC
Jan 2018
2018 Round of Funding Four new Projects announced
Jun 2018
Exciting regrowth of nerve fibres
Jun 2018
Dr Merson secures $1 million from NHMRC
Jun 2018
Findings submitted for publication
Jan 2017
New Research Projects commencing 2017 announced

Treating MS with cell and gene
therapy

Summary

The number and type of therapies we have for treating MS is continually growing. In the future, it may be possible to treat MS with cell-based therapies. In this method, specialised cells grown in the laboratory would be injected or transplanted into a person with MS, where they would release chemicals that can help fight the disease.

One of the major obstacles with cell-based therapies is controlling the growth of the cells once they are transplanted into a person. As these cells are similar to stem cells, they have the potential to grow into tumours and other unwanted growths. Dr Andras Nagy from the Australian Regenerative Medicine Institute, has developed a patented way to prevent this uncontrolled growth. In this incubator grant, Dr Natalie Payne from Monash University, will be adapting these cells to develop a potential therapy for MS.

Dr Payne is investigating a chemical called IL-1Beta that is released by cells in the immune system. This chemical has been associated with the initiation and maintenance of chronic or long lasting neuroinflammation, damage to the neurons, and demyelination, all of which result in the neurological symptoms of MS.

Dr Payne aims to create cells that will release a chemical that binds to IL-1Beta, thereby preventing it from initiating the pathway that leads to damages to the neuronal tissues. Dr Payne will then transplant these cells into a laboratory model of MS, and determine if they can prevent neuroinflammation and demyelination.

This clinically relevant project will determine if this approach can limit key steps in the pathway to tissue destruction, but also validate that cell-based therapies for MS are a feasible option.

 

Trish Foundation & MS Research Australia Working together to find a cure for MS
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