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Feb 2017
Trish Foundation contributes to first-ever discovery
Jun 2017
Researchers funded by the Trish Foundation making great progress
Dec 2014
2015 Funding announced
Mar 2015
Investigating new treatment options
Oct 2015
Progress in MS Research Conference
Feb 2016
2016 Round of Funding
Sep 2016
Dr Gu's Incubator Grant announced
Jan 2017
New Research Projects commencing 2017 announced

Does stimulating brain activity
improve myelin repair?

 

Project Grant - $120,000 over 2017-2018 funded by the Trish Multiple Sclerosis Research Foundation

Investigator:
Dr Toby Merson, Monash University, Victoria  

Co-Investigator:
Dr Stanislaw Mitew, Monash University, Victoria

Summary

MS results from the damage and loss of myelin, the conductive layer around nerve fibres in the brain and spinal cord. Myelin can be repaired, but this process is incomplete and failure of this repair is thought to underlie conversion to secondary progressive MS. During progressive phases of MS, the nerve fibre itself is directly damaged and currently this is impossible to reverse, leading to the accumulation of disability.

Dr Merson’s team have shown that increasing the electrical activity of nerve fibres in brain tissue that is not affected by MS enhances the laying down of myelin on these nerve fibres. Other research has recently shown that blocking electrical activity in lesions within the MS brain reduces the brain’s ability to repair the lost myelin. In this project Dr Merson will test whether electrical activity within nerve cells alters the ability of myelin to be repaired in laboratory models of MS. Determining new ways to enhance repair in the MS brain will hopefully lead to new therapeutic options for the progressive phase of MS in the future.   MS results from the damage and loss of myelin, the conductive layer around nerve fibres in the brain and spinal cord. Myelin can be repaired, but this process is incomplete and failure of this repair is thought to underlie conversion to secondary progressive MS. During progressive phases of MS, the nerve fibre itself is directly damaged and currently this is impossible to reverse, leading to the accumulation of disability. Dr Merson’s team have shown that increasing the electrical activity of nerve fibres in brain tissue that is not affected by MS enhances the laying down of myelin on these nerve fibres. Other research has recently shown that blocking electrical activity in lesions within the MS brain reduces the brain’s ability to repair the lost myelin. In this project Dr Merson will test whether electrical activity within nerve cells alters the ability of myelin to be repaired in laboratory models of MS.

Determining new ways to enhance repair in the MS brain will hopefully lead to new therapeutic options for the progressive phase of MS in the future.  

Trish Foundation & MS Research Australia Working together to find a cure for MS
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