A novel approach to reduce
impact of progressive MS
Monash University, Victoria
Professor Frank Alderuccio, Monash University, Victoria
Grant - $160,000 over 2016-2017
full funding support from the Trish Multiple Sclerosis Research Foundation
Dr Petratos is the only Australian researcher to receive funding from
the International Progressive MS Alliance in their inaugural round of funding.
This Project Grant is a continuation of this research.
The International Progressive MS Alliance is working
together to connect resources and experts around the world to find answers and
develop solutions to end progressive MS.
MS Research Australia, with whom the Foundation works closely, has
joined MS organisations from around the world in a global alliance to end
progressive MS. Coordinated by the MSIF,
this Alliance is the most ambitious collaborative project the global MS
movement has ever embarked upon.
progressive phase of MS is thought to result from damage to the nerve fibre
rather than the direct inflammatory attack on myelin. Dr Petratos has been
working on determining which molecules are responsible for this nerve fibre
Petratos will look at how damage occurs in nerve fibres with progressive
clinical symptoms in laboratory models of MS, specifically they will
investigate a receptor molecule known as NgR1 and attempt to block the receptor
molecule in nerve cells. The blocking agent of NgRI will be delivered using a
highly novel method that will allow accurate targeting of the NgR1 receptor.
targeting these molecules during MS it may be possible to limit the destruction
which occurs to nerve fibres in the brain and spinal cord, giving a better
clinical outcome for people with MS.