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Jun 2014
Predicting MS in children
Oct 2014
Three new Incubator Grants announced
Dec 2014
2015 Funding announced
Mar 2015
Investigating new treatment options
Oct 2015
Progress in MS Research Conference
Feb 2016
2016 Round of Funding
Feb 2014
New projects being funded
Feb 2014
Breakthrough study shows great promise

Subclinical disease progression

and repair in multiple sclerosis: 

novel application of standardised

functional visual biomarkers 

     

Postgraduate Scholarship - $67,000 over 2017-2018 funded by the Trish Multiple Sclerosis Research Foundation

Investigator:       
Dr Joshua Barton, Brain and Mind Centre, University of Sydney, NSW

Supervisor:      
Associate Professor Michael Barnett, Brain and Mind Centre, University of Sydney, NSW

Summary

The current methods available to clinicians and researchers to measure the progression of disease and disability in people with MS are relatively insensitive and must be measured over relatively long periods of time. However, people with early MS often have changes to their brains which do not result in symptoms, so called ‘sub-clinical changes’ which can affect disability later in the disease. Clinical trials for medications that aim to slow or halt disability progression are also hampered by this lack of sensitive measures for progression.

Dr Barton, a clinician currently receiving advanced training in neurology, will undertake a postgraduate scholarship to develop a tablet based tool that will track sub-clinical changes in real-time.

The tests, that can be easily administered in the clinic, or for the first time, in a person’s home, will measure aspects of the visual system - the eyes and the parts of the brain that process vision. The tablet based testing will be recorded over time and compared with more traditional measures of relapse activity and disability, measurements taken by advanced magnetic resonance imaging (MRI) and other markers of disturbance to the visual pathway.

Dr Barton will also determine whether these visual measurements also show improvement in people who improve clinically after commencing highly effective disease modifying therapy for their MS. It is expected this research will yield a novel tool able to be used in clinical trials and in the clinic to monitor disease progression and the effectiveness of therapies for MS in the real world setting.

Trish Foundation & MS Research Australia Working together to find a cure for MS
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